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Sumatriptan

  1. Blocks pain signals from nerves
  2. Makes blood vessel openings smaller

Naproxen

  1. Reduces inflammation in the covering of the brain (meninges)

The exact mechanism of action is not known.

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TREXIMET® for Pediatric Patients

If you have a child 12 to 17 years of age who suffers from acute migraines, you may have struggled in the past to find a medicine that will help treat the pain. Or you may not have sought treatment at all.

Very few prescription medicines have been studied and approved to treat pediatric patients 12 to 17 years of age with migraine.

TREXIMET® is the only medicine that combines sumatriptan with naproxen that is approved for use to treat acute migraines in pediatric patients 12 to 17 years of age in the United States.

The effectiveness of TREXIMET® was studied in 490 pediatric patients 12 to 17 years of age, with 96 patients taking the recommended dose of 10 mg sumatriptan/60 mg naproxen.

In that study, nearly 9 out of 10 pediatric migraine sufferers did not need a rescue medicine after taking TREXIMET®.

This means TREXIMET® alone gave them relief and they did not need to take any other medicine between 2 and 24 hours after taking TREXIMET®.

In that same study:

29% experienced pain freedom 2 hours after treatment

24% of patients experienced pain freedom that started after 2 hours and lasted for 24 hours

Keep track of your migraines

Find out how your Migraine Tracker can help you keep a treatment record of your migraines, manage your symptoms, and have open and productive discussions with your doctor.Learn more now!

How safe is TREXIMET®?

The safety of TREXIMET® has been studied in over 991 pediatric patients 12 to 17 years of age in 3 separate clinical trials

The most common side effects of TREXIMET® include dizziness; feeling weak, drowsy, or tired; pain, discomfort, or stiffness in your neck, throat, jaw, or chest; nausea; tingling or numbness in your fingers or toes; heartburn; dry mouth; feeling hot; heartbeat problems; and muscle tightness.

The most common adverse reactions in clinical trials of pediatric patients 12 to 17 are reported to be hot flush (i.e., hot flash[es]) and muscle tightness.

TREXIMET® may increase your chance of a heart attack or stroke that can lead to death. TREXIMET® contains 2 medicines: sumatriptan and naproxen sodium (a nonsteroidal anti-inflammatory drug [NSAID]).

Your chance of a heart attack or stroke increases with longer use of NSAID medicines or if you have heart disease.

Stop taking TREXIMET® and get emergency help right away if you have any of the following symptoms of a heart attack or stroke:

  • discomfort in the center of your chest that lasts for more than a few minutes, or that goes away and comes back
  • severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw
  • pain or discomfort in your arms, back, neck, jaw, or stomach
  • shortness of breath with or without chest discomfort
  • breaking out in a cold sweat
  • nausea or vomiting
  • feeling lightheaded
  • weakness in one part or on one side of your body
  • slurred speech

TREXIMET® is not for people with risk factors for heart disease unless a heart exam is done and shows no problem. You have a higher risk for heart disease if you:

  • have high blood pressure
  • have high cholesterol levels
  • smoke
  • are overweight
  • have diabetes
  • have a family history of heart disease

TREXIMET® should never be used if you have ever had a heart surgery called a coronary artery bypass graft (CABG).

TREXIMET® can cause ulcers and bleeding in the stomach and intestines at any time during your treatment. Ulcers and bleeding can happen without warning symptoms and may cause death.

Your chance of getting an ulcer or bleeding increases with:

  • the use of medicines called steroid hormones and blood thinners
  • more frequent use
  • drinking alcohol
  • having poor health
  • longer use
  • smoking
  • older age

TREXIMET® may cause serious allergic reactions or serious skin reactions that can be life-threatening. Stop taking TREXIMET® and get emergency help right away if you develop:

  • sudden wheezing
  • rash
  • problems breathing or swallowing
  • blisters or bleeding of your lips, eyelids, mouth, nose, or genitals
  • swelling of your lips, tongue, throat or body
  • fainting
  • reddening of your skin with blisters or peeling

TREXIMET® should only be used exactly as prescribed, at the lowest dose possible for your treatment, and for the shortest time needed.

TREXIMET® already contains an NSAID (naproxen). Do not use TREXIMET® with other medicines to lessen pain or fever without talking to your healthcare provider first, because they may contain an NSAID also.

To learn more about what you may expect when your child takes TREXIMET®, read the Patient Medication Guide and talk with your healthcare provider about all the benefits and risks of taking TREXIMET®.

Tell your healthcare provider about any side effects that bother your child or that do not go away.

The safety of treating an average of more than 2 migraine headaches in adolescents in a 30-day period has not been established.

Keep track of your migraines

Find out how your Migraine Tracker can help you keep a treatment record of your migraines, manage your symptoms, and have open and productive discussions with your doctor.Learn more now!

Recommended dose of TREXIMET® for your child

The recommended dose for pediatric patients 12 to 17 years of age is a single tablet of TREXIMET® (10 mg sumatriptan/60 mg naproxen) per 24-hour period.

A majority of patients treated with TREXIMET® only needed a single tablet to find relief.

The maximum recommended single dose in pediatric patients is 85 mg sumatriptan/500 mg naproxen per 24-hour period. If your child takes too much TREXIMET®, call your healthcare provider or go to the nearest hospital emergency room right away.

For pediatric patients 12 to 17 years of age, it is not known if taking more than 1 dose of TREXIMET® in 24 hours is safe and effective.

Talk to your healthcare provider about what to do if your child’s headache does not go away or comes back.

TREXIMET® can be taken with or without food.

Do not split, crush, or chew TREXIMET® tablets.

Certain people should take their first dose of TREXIMET® in their healthcare provider’s office or in another medical setting. Ask your healthcare provider if this is necessary for your child’s first dose.

Consider keeping a record of your child’s migraines and when they take TREXIMET® so you can talk with your healthcare provider about how TREXIMET® is working for them.

Register for useful information

Learn when new product information or programs about TREXIMET® become available.Sign up now!

PATIENT IMPORTANT SAFETY INFORMATION

What is the most important information I should know about TREXIMET® (sumatriptan/naproxen sodium)?

TREXIMET® may increase your chance of a heart attack or stroke that can lead to death. TREXIMET® contains 2 medicines: sumatriptan and naproxen sodium (a nonsteroidal anti-inflammatory drug [NSAID]).

  • This risk may happen early in treatment and may increase:
    • with increasing doses of NSAIDs
    • with longer use of NSAIDs.

Do not take TREXIMET® right before or after a heart surgery called a “coronary artery bypass graft (CABG)."

Avoid taking TREXIMET® after a recent heart attack, unless your healthcare provider tells you to. You may have an increased risk of another heart attack if you take NSAIDs after a recent heart attack.

Stop taking TREXIMET® and get emergency help right away if you have any of the following symptoms of a heart attack or stroke:

  • discomfort in the center of your chest that lasts for more than a few minutes, or that goes away and comes back
  • severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw
  • pain or discomfort in your arms, back, neck, jaw, or stomach
  • shortness of breath with or without chest discomfort
  • breaking out in a cold sweat
  • nausea or vomiting
  • feeling lightheaded
  • weakness in one part or on one side of your body
  • slurred speech

TREXIMET® is not for people with risk factors for heart disease unless a heart exam is done and shows no problem. You have a higher risk for heart disease if you:

  • have high blood pressure
  • have high cholesterol levels
  • smoke
  • are overweight
  • have diabetes
  • have a family history of heart disease

TREXIMET® can cause ulcers and bleeding in the stomach and intestines at any time during your treatment.
Ulcers and bleeding
can happen without warning symptoms and may cause death.

Your chance of getting an ulcer or bleeding increases with:

  • past history of stomach ulcers, or stomach or intestinal bleeding with use of NSAIDs
  • the use of medicines called “corticosteroids,” “anticoagulants,” and antidepressant medicines called “SSRIs” or “SNRIs”
  • longer use
  • more frequent use
  • smoking
  • drinking alcohol
  • older age
  • having poor health
  • advanced liver disease
  • bleeding problems

TREXIMET® may cause serious allergic reactions or serious skin reactions that can be life-threatening. Stop taking TREXIMET® and get emergency help right away if you develop:

  • sudden wheezing
  • swelling of your lips, tongue, throat or body
  • rash
  • fainting
  • problems breathing or swallowing
  • reddening of your skin with blisters or peeling
  • blisters or bleeding of your lips, eye lids, mouth, nose, or genitals

TREXIMET® should only be used exactly as prescribed, at the lowest dose possible for your treatment, and for the shortest time needed.

TREXIMET® already contains an NSAID (naproxen). Do not use TREXIMET® with other medicines to lessen pain or fever or with other medicines for colds or sleeping problems without talking to your healthcare provider first, because they may contain an NSAID also.

What is TREXIMET®?

TREXIMET® is a prescription medicine that contains sumatriptan and naproxen sodium (an NSAID). TREXIMET® is used to treat acute migraine headaches with or without aura in patients 12 years of age and older.

TREXIMET® is not used to treat other types of headaches such as hemiplegic (that make you unable to move on one side of your body) or basilar (rare form of migraine with aura) migraines.

TREXIMET® is not used to prevent or decrease the number of migraine headaches you have.

It is not known if TREXIMET® is safe and effective to treat cluster headaches.

Who should not take TREXIMET®?

Do not take TREXIMET® if you have:

  • heart problems, history of heart problems, or right before or after heart bypass surgery
  • had a stroke, transient ischemic attack (TIAs), or problems with your blood circulation
  • hemiplegic migraines or basilar migraines. If you are not sure if you have these types of migraines, ask your healthcare provider.
  • narrowing of blood vessels to your legs and arms (peripheral vascular disease), stomach (ischemic bowel disease), or kidneys
  • uncontrolled high blood pressure
  • taken any medicines in the last 24 hours that are called 5-HT1 agonists that are triptans or contain ergotamine. Ask your healthcare provider for a list of these medicines if you are not sure.
  • taken an antidepressant medicine called a monoamine oxidase (MAO) inhibitor within the last 2 weeks. Ask your healthcare provider for a list if you are not sure.
  • had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine
  • an allergy to sumatriptan, naproxen, or any of the ingredients in TREXIMET®. See “What are the ingredients in TREXIMET®?” below for a complete list of ingredients.
  • third trimester of pregnancy
  • liver problems

What should I tell my healthcare provider before taking TREXIMET®?

Before you take TREXIMET®, tell your healthcare provider about all of your medical conditions, including if you:

  • have high blood pressure
  • have asthma
  • have high cholesterol
  • have diabetes
  • smoke
  • are overweight
  • have heart problems or a family history of heart problems or stroke
  • have kidney problems
  • have liver problems
  • have had epilepsy or seizures
  • are not using effective birth control
  • are pregnant, think you might be pregnant, or are trying to become pregnant. TREXIMET® should not be used by pregnant women during the third trimester of their pregnancy.
  • are breastfeeding or plan to breastfeed. The components of TREXIMET® pass into your breast milk and may harm your baby. Talk with your healthcare provider about the best way to feed your baby if you take TREXIMET®.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

TREXIMET® and certain other medicines can affect each other, causing serious side effects.

What should I avoid while taking TREXIMET®?®?

TREXIMET® can cause dizziness, weakness, or drowsiness. If you have these symptoms, do not drive a car, use machinery, or do anything where you need to be alert.

What are the possible side effects of TREXIMET®?

TREXIMET® may cause serious side effects. See “What is the most important information I should know about TREXIMET®?”

These serious side effects include:

  • changes in color or sensation in your fingers and toes (Raynaud’s syndrome)
  • new or worse high blood pressure
  • heart failure from body swelling (fluid retention)
  • kidney problems including kidney failure
  • low red blood cells (anemia)
  • liver problems including liver failure
  • asthma attacks in people who have asthma
  • stomach and intestinal problems (gastrointestinal and colonic ischemic events). Symptoms of gastrointestinal and colonic ischemic events include:
    • sudden or severe stomach pain
    • stomach pain after meals
    • weight loss
    • nausea or vomiting
    • constipation or diarrhea
    • bloody diarrhea
    • fever
  • problems with blood circulation to your legs and feet (peripheral vascular ischemia). Symptoms of peripheral vascular ischemia include:
    • cramping and pain in your legs or hips
    • feeling of heaviness or tightness in your leg muscles
    • burning or aching pain in your feet or toes while resting
    • numbness, tingling, or weakness in your legs
    • cold feeling or color changes in 1 or both legs or feet
  • medication overuse headaches. Some people who use too many TREXIMET® tablets may have worse headaches (medication overuse headache). If your headaches get worse, your healthcare provider may decide to stop your treatment with TREXIMET®.
  • serotonin syndrome. Serotonin syndrome is a rare but serious problem that can happen in people using TREXIMET®, especially if TREXIMET® is used with antidepressant medicines called SSRIs or SNRIs.
  • Stop taking TREXIMET® and call your healthcare provider right away if you have any of the following symptoms of serotonin syndrome:
    • changes in blood pressure
    • fast heartbeat
    • tight muscles
    • high body temperature
    • mental changes such as seeing things that are not there (hallucinations), agitation, or coma
    • trouble walking
  • seizures. Seizures have happened in people taking sumatriptan, one of the ingredients in TREXIMET®, who have never had seizures before. Talk with your healthcare provider about your chance of having seizures while you take TREXIMET®.

The most common side effects of TREXIMET® include:

  • dizziness
  • feeling weak, drowsy, or tired
  • pain, discomfort, or stiffness in your neck, throat, jaw, or chest
  • nausea
  • heartburn
  • tingling or numbness in your fingers or toes
  • feeling hot
  • dry mouth
  • muscle tightness
  • heartbeat problems

Stop TREXIMET® and call your healthcare provider right away if you have any of the following symptoms:

  • nausea that seems out of proportion to your migraine
  • sudden or severe stomach pain
  • blood in your bowel movement or it is black and sticky like tar
  • vomit blood
  • yellow skin or eyes
  • unusual weight gain
  • more tired or weaker than usual
  • flu-like symptoms
  • itching
  • diarrhea
  • swelling of the arms, legs, hands, and feet
  • tenderness in your upper right side

These are not all of the possible side effects of TREXIMET®. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

For more information, please see the complete Prescribing Information, including BOXED WARNINGS, and the Medication Guide.

References: 1. National Headache Foundation. Satisfaction Survey. /p.1/para 5. Accessed on April 26, 2016. http://www.lipigesic.com/files/2011/10/NHF-Critical-Demand-Migraine-Relief.pdf 2. Brandes JL, Kudrow D, Stark SR, et al. Sumatriptan-naproxen for acute treatment of migraine: a randomaized trial. JAMA. 2007;297:1443-1454. 3. National Institute of Neurological Disorders and Stroke. “Headache: Hope Through Research.” Accessed on March 17, 2016. http://www.ninds.nih.gov/disorders/headache/detail_headache.htm 4. Migraine Research Foundation. “Migraine in Women.” Accessed on April 26, 2016. http://www.migraineresearchfoundation.org/Migraine%20in%20Women.html

PATIENT IMPORTANT SAFETY INFORMATION

What is the most important information I should know about TREXIMET® (sumatriptan/naproxen sodium)?

TREXIMET® may increase your chance of a heart attack or stroke that can lead to death. TREXIMET® contains 2 medicines: sumatriptan and naproxen sodium (a nonsteroidal anti-inflammatory drug [NSAID]).

  • This risk may happen early in treatment and may increase:
    • with increasing doses of NSAIDs
    • with longer use of NSAIDs.

Do not take TREXIMET® right before or after a heart surgery called a “coronary artery bypass graft (CABG)."

Avoid taking TREXIMET® after a recent heart attack, unless your healthcare provider tells you to. You may have an increased risk of another heart attack if you take NSAIDs after a recent heart attack.

Stop taking TREXIMET® and get emergency help right away if you have any of the following symptoms of a heart attack or stroke:

  • discomfort in the center of your chest that lasts for more than a few minutes, or that goes away and comes back
  • severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw
  • pain or discomfort in your arms, back, neck, jaw, or stomach
  • shortness of breath with or without chest discomfort
  • breaking out in a cold sweat
  • nausea or vomiting
  • feeling lightheaded
  • weakness in one part or on one side of your body
  • slurred speech

TREXIMET® is not for people with risk factors for heart disease unless a heart exam is done and shows no problem. You have a higher risk for heart disease if you:

  • have high blood pressure
  • have high cholesterol levels
  • smoke
  • are overweight
  • have diabetes
  • have a family history of heart disease

TREXIMET® can cause ulcers and bleeding in the stomach and intestines at any time during your treatment.
Ulcers and bleeding
can happen without warning symptoms and may cause death.

Your chance of getting an ulcer or bleeding increases with:

  • past history of stomach ulcers, or stomach or intestinal bleeding with use of NSAIDs
  • the use of medicines called “corticosteroids,” “anticoagulants,” and antidepressant medicines called “SSRIs” or “SNRIs”
  • longer use
  • more frequent use
  • smoking
  • drinking alcohol
  • older age
  • having poor health
  • advanced liver disease
  • bleeding problems

TREXIMET® may cause serious allergic reactions or serious skin reactions that can be life-threatening. Stop taking TREXIMET® and get emergency help right away if you develop:

  • sudden wheezing
  • swelling of your lips, tongue, throat or body
  • rash
  • fainting
  • problems breathing or swallowing
  • reddening of your skin with blisters or peeling
  • blisters or bleeding of your lips, eye lids, mouth, nose, or genitals

TREXIMET® should only be used exactly as prescribed, at the lowest dose possible for your treatment, and for the shortest time needed.

TREXIMET® already contains an NSAID (naproxen). Do not use TREXIMET® with other medicines to lessen pain or fever or with other medicines for colds or sleeping problems without talking to your healthcare provider first, because they may contain an NSAID also.

What is TREXIMET®?

TREXIMET® is a prescription medicine that contains sumatriptan and naproxen sodium (an NSAID). TREXIMET® is used to treat acute migraine headaches with or without aura in patients 12 years of age and older.

TREXIMET® is not used to treat other types of headaches such as hemiplegic (that make you unable to move on one side of your body) or basilar (rare form of migraine with aura) migraines.

TREXIMET® is not used to prevent or decrease the number of migraine headaches you have.

It is not known if TREXIMET® is safe and effective to treat cluster headaches.

Who should not take TREXIMET®?

Do not take TREXIMET® if you have:

  • heart problems, history of heart problems, or right before or after heart bypass surgery
  • had a stroke, transient ischemic attack (TIAs), or problems with your blood circulation
  • hemiplegic migraines or basilar migraines. If you are not sure if you have these types of migraines, ask your healthcare provider.
  • narrowing of blood vessels to your legs and arms (peripheral vascular disease), stomach (ischemic bowel disease), or kidneys
  • uncontrolled high blood pressure
  • taken any medicines in the last 24 hours that are called 5-HT1 agonists that are triptans or contain ergotamine. Ask your healthcare provider for a list of these medicines if you are not sure.
  • taken an antidepressant medicine called a monoamine oxidase (MAO) inhibitor within the last 2 weeks. Ask your healthcare provider for a list if you are not sure.
  • had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine
  • an allergy to sumatriptan, naproxen, or any of the ingredients in TREXIMET®. See “What are the ingredients in TREXIMET®?” below for a complete list of ingredients.
  • third trimester of pregnancy
  • liver problems

What should I tell my healthcare provider before taking TREXIMET®?

Before you take TREXIMET®, tell your healthcare provider about all of your medical conditions, including if you:

  • have high blood pressure
  • have asthma
  • have high cholesterol
  • have diabetes
  • smoke
  • are overweight
  • have heart problems or a family history of heart problems or stroke
  • have kidney problems
  • have liver problems
  • have had epilepsy or seizures
  • are not using effective birth control
  • are pregnant, think you might be pregnant, or are trying to become pregnant. TREXIMET® should not be used by pregnant women during the third trimester of their pregnancy.
  • are breastfeeding or plan to breastfeed. The components of TREXIMET® pass into your breast milk and may harm your baby. Talk with your healthcare provider about the best way to feed your baby if you take TREXIMET®.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

TREXIMET® and certain other medicines can affect each other, causing serious side effects.

What should I avoid while taking TREXIMET®?®?

TREXIMET® can cause dizziness, weakness, or drowsiness. If you have these symptoms, do not drive a car, use machinery, or do anything where you need to be alert.

What are the possible side effects of TREXIMET®?

TREXIMET® may cause serious side effects. See “What is the most important information I should know about TREXIMET®?”

These serious side effects include:

  • changes in color or sensation in your fingers and toes (Raynaud’s syndrome)
  • new or worse high blood pressure
  • heart failure from body swelling (fluid retention)
  • kidney problems including kidney failure
  • low red blood cells (anemia)
  • liver problems including liver failure
  • asthma attacks in people who have asthma
  • stomach and intestinal problems (gastrointestinal and colonic ischemic events). Symptoms of gastrointestinal and colonic ischemic events include:
    • sudden or severe stomach pain
    • stomach pain after meals
    • weight loss
    • nausea or vomiting
    • constipation or diarrhea
    • bloody diarrhea
    • fever
  • problems with blood circulation to your legs and feet (peripheral vascular ischemia). Symptoms of peripheral vascular ischemia include:
    • cramping and pain in your legs or hips
    • feeling of heaviness or tightness in your leg muscles
    • burning or aching pain in your feet or toes while resting
    • numbness, tingling, or weakness in your legs
    • cold feeling or color changes in 1 or both legs or feet
  • medication overuse headaches. Some people who use too many TREXIMET® tablets may have worse headaches (medication overuse headache). If your headaches get worse, your healthcare provider may decide to stop your treatment with TREXIMET®.
  • serotonin syndrome. Serotonin syndrome is a rare but serious problem that can happen in people using TREXIMET®, especially if TREXIMET® is used with antidepressant medicines called SSRIs or SNRIs.
  • Stop taking TREXIMET® and call your healthcare provider right away if you have any of the following symptoms of serotonin syndrome:
    • changes in blood pressure
    • fast heartbeat
    • tight muscles
    • high body temperature
    • mental changes such as seeing things that are not there (hallucinations), agitation, or coma
    • trouble walking
  • seizures. Seizures have happened in people taking sumatriptan, one of the ingredients in TREXIMET®, who have never had seizures before. Talk with your healthcare provider about your chance of having seizures while you take TREXIMET®.

The most common side effects of TREXIMET® include:

  • dizziness
  • feeling weak, drowsy, or tired
  • pain, discomfort, or stiffness in your neck, throat, jaw, or chest
  • nausea
  • heartburn
  • tingling or numbness in your fingers or toes
  • feeling hot
  • dry mouth
  • muscle tightness
  • heartbeat problems

Stop TREXIMET® and call your healthcare provider right away if you have any of the following symptoms:

  • nausea that seems out of proportion to your migraine
  • sudden or severe stomach pain
  • blood in your bowel movement or it is black and sticky like tar
  • vomit blood
  • yellow skin or eyes
  • unusual weight gain
  • more tired or weaker than usual
  • flu-like symptoms
  • itching
  • diarrhea
  • swelling of the arms, legs, hands, and feet
  • tenderness in your upper right side

These are not all of the possible side effects of TREXIMET®. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

For more information, please see the complete Prescribing Information, including BOXED WARNINGS, and the Medication Guide.

References: 1. National Headache Foundation. Satisfaction Survey. /p.1/para 5. Accessed on April 26, 2016. http://www.lipigesic.com/files/2011/10/NHF-Critical-Demand-Migraine-Relief.pdf 2. Brandes JL, Kudrow D, Stark SR, et al. Sumatriptan-naproxen for acute treatment of migraine: a randomaized trial. JAMA. 2007;297:1443-1454. 3. National Institute of Neurological Disorders and Stroke. “Headache: Hope Through Research.” Accessed on March 17, 2016. http://www.ninds.nih.gov/disorders/headache/detail_headache.htm 4. Migraine Research Foundation. “Migraine in Women.” Accessed on April 26, 2016. http://www.migraineresearchfoundation.org/Migraine%20in%20Women.html